SS-31 50mg | Elamipretide Mitochondrial Research |

⚠️ ATTENTION: STRICTLY FOR LABORATORY RESEARCH USE ONLY.

This product is NOT FOR HUMAN CONSUMPTION, medical use, veterinary use, or diagnostic use. By purchasing, you agree to handle this compound in compliance with all local and federal regulations. No medical or clinical advice is provided; this description serves exclusively as a biochemical and mechanistic overview for advanced research purposes.

SS-31 (Elamipretide) 50mg – The Apex of Mitochondrial Structural Engineering

SS-31, widely known in scientific literature as Elamipretide (or Bendavia), represents a monumental leap in the laboratory investigation of cellular bio-energetics and age-related mitochondrial dysfunction. Classified as a Szeto-Schiller (SS) tetrapeptide, SS-31 is a uniquely engineered compound capable of penetrating the cell membrane and selectively targeting the Inner Mitochondrial Membrane (IMM).

In the specialized landscape of molecular biology and longevity science, SS-31 is regarded as a “structural” peptide. While most metabolic research focuses on extracellular signaling or nuclear transcription, SS-31 operates at the physical level of the cellular “powerhouse.” It is the definitive compound for investigating the preservation of mitochondrial architecture under extreme oxidative stress. By optimizing how cells produce and utilize energy at the most fundamental source, this 50mg formulation provides researchers with a robust tool to study the biological mechanics of longevity, fatigue resistance, and cardiovascular resilience.

The Biochemistry of Cardiolipin Binding & Structural Stability

To understand the profound research value of the SS-31 50mg yield, investigators must examine its precise intracellular mechanism of action—specifically its interaction with Cardiolipin.

1. Cardiolipin Stabilization: Cardiolipin is a unique, cone-shaped phospholipid found almost exclusively in the inner mitochondrial membrane. It is the “glue” required to anchor the protein complexes of the Electron Transport Chain (ETC) into their proper functional shapes. Under high oxidative stress, cardiolipin undergoes peroxidation, causing the ETC complexes to destabilize and separate. SS-31 selectively binds to cardiolipin via electrostatic and hydrophobic interactions, physically protecting it from oxidative degradation and maintaining the structural integrity of the mitochondrial cristae.

2. Optimized Electron Transport & ATP Output: When cardiolipin is stabilized by SS-31, the Electron Transport Chain operates at peak efficiency. This prevents the “leakage” of electrons, ensuring that the maximum amount of cellular energy—Adenosine Triphosphate (ATP)—is synthesized. In research models of cellular exhaustion, SS-31 is used to investigate whether restoring structural stability can reverse systemic fatigue.

3. Targeted $ROS$ Mitigation: Because SS-31 prevents electron leakage at the source, it drastically reduces the production of Reactive Oxygen Species (ROS). Unlike traditional systemic antioxidants (like Vitamin C or E) which can indiscriminately neutralize necessary signaling molecules, SS-31 reduces pathological oxidative stress directly at the site of mitochondrial energy production without disrupting healthy cellular communication.

Primary Domains of Laboratory Investigation

Detailed Breakdown of Research Applications

I. Cardiovascular Function & Ischemia-Reperfusion Modeling

One of the most clinically explored applications of SS-31 is in cardiovascular research. During a cardiac event (ischemia), blood flow is restricted, and when it returns (reperfusion), the sudden rush of oxygen causes a massive, destructive spike in mitochondrial ROS. Researchers utilize SS-31 to study its ability to shield cardiac cells from this “ischemia-reperfusion injury.” Laboratory data suggests that by stabilizing cardiolipin, researchers can observe how heart muscle maintains efficient ATP production and recovers faster from acute trauma, making it a cornerstone for studying myocardial health.

II. Reversing Cellular Aging and Mitochondrial Decay

As organisms age, mitochondrial DNA mutates, and cardiolipin degrades, leading to a vicious cycle of lower energy output and higher oxidative damage. SS-31 is a premier subject of longevity research because it targets this specific root cause of aging. Laboratory models use SS-31 to investigate the restoration of youthful mitochondrial dynamics, looking for structural improvements in muscle, brain, and organ tissue over extended temporal studies. It essentially serves as a “rehabilitation” compound for the cell’s engine.

III. Muscle Endurance and Fatigue Resistance

By maximizing the efficiency of the Electron Transport Chain, SS-31 is heavily modeled in performance biology. Researchers observe how skeletal muscle behaves when it is supplied with an uninterrupted, highly efficient flow of ATP, accompanied by a reduction in damaging oxidative byproducts. This makes it an ideal research subject for studying treatments for chronic fatigue syndromes and age-related sarcopenia (muscle loss).

Comparative Advantage: SS-31 vs. NAD⁺ vs. MOTS-c

In advanced mitochondrial bio-optimization protocols, scientists must distinguish between Fuel, Signaling, and Structure:

• NAD⁺ (Coenzyme): Provides the Fuel. It acts as the biological currency required to transfer electrons through the mitochondria.

• MOTS-c (MDP): Provides the Signal. It acts as a messenger, traveling from the mitochondria to the nucleus to activate AMPK and improve metabolic sensing.

• SS-31 (Elamipretide): Provides the Structure. It physically repairs and stabilizes the mitochondrial machinery (cardiolipin) so that the fuel (NAD⁺) can be processed efficiently without breaking down the engine.

Laboratory Specifications & Compound Profile

This ultra-premium formulation is synthesized exclusively for rigorous laboratory environments demanding absolute molecular stability, high purity, and verified structural integrity.

• Product Classification: Szeto-Schiller (SS) Mitochondrial Tetrapeptide.

• Chemical Name / Identifier: Elamipretide / SS-31.

• Molecular Weight: 639.8 g/mol.

• Dosage / Yield: High-Purity 50mg (50,000mcg) Lyophilized Powder.

• Vial Capacity: Standard 10ML clinical research format.

• Purity Standard: 99%+ (Independent Third-Party Lab Verified via HPLC and Mass Spectrometry).

• Storage Requirements: Store lyophilized powder at -20°C for maximum long-term stability. Avoid repeated freeze-thaw cycles. Once reconstituted with bacteriostatic water, refrigerate immediately at 2°C to 8°C.

Summary of Research Potential :

SS-31 (Elamipretide) 50mg is an advanced, mitochondria-targeting tetrapeptide engineered for longevity and cellular health research. By selectively binding to and stabilizing cardiolipin on the inner mitochondrial membrane, SS-31 allows researchers to investigate the optimization of ATP production, the targeted reduction of oxidative stress (ROS), and the preservation of cardiovascular and neurological tissue under severe metabolic stress. If metabolic peptides change how an organism uses fuel, SS-31 improves how the cells produce energy at the source. It is the definitive foundational compound for researching the biological architecture of cellular performance.